조직 투명화 장치Logos Biosystems > X-CLARITY™

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지질이 제거된 투명한 조직을 만드는 장비

생체 조직의 lipid를 빠르게 제거 후 투명화된 조직을 얻을 수 있고, 형광 염색을 통해 완벽한 3D 이미지를 확인할 수 있습니다.

 - 조직 투명화 기술의 가장 진보된 방법으로, 우수한 투명도

 - 현존하는 기술 중 가장 빠른 조직 투명화 방법

 - 최적화된 protocol

 - 일정한 electric current와 온도 control로 샘플 burning, melting, black precipitation, bubble 형성 최소화




(1) X-CLARITYTM Polymerization System (Optional; Cat. no. C20001) 

  - Tissue-hydrogel hybridization은 최적의 tissue clearing 결과를 보기위해 꼭 거쳐야 하는 과정

  - 자동화 system을 통해 anaerobic 상태에서 일정한 온도 아래 polymerization 과정을 진행

(2) X-CLARITY ETC Control Tower

  - 전원, 온도, buffer circulation을 조절

  - 두 가지 power supply modes: constant current, constant voltage

  - 온도 조절을 통해 buffer cooling, heating 가능

  - LCD tochscreen으로 쉽게 조작

  - Tissue clearing condition 모니터링 가능

(3) X-CLARITY ETC Chamber

  - Tissue clearing chamber

  - 일정한 전류의 흐름

  - Built-in cooling system

(4) X-CLARITY Buffer Reservoir

(5) X-CLARITY Tray




CLARITYTM 란?
  • Hydrogel network 형성을 통해  지질이 제거된 투명한 조직을 만드는 기술(Stanford University Deisseroth Lab, Chung et al, Nature 497:332-337)
  • antibody, nucleic acid와 같은 macromolecule labeling이 가능하고, 높은 해상도의 이미지 구현 가능




조직별 X-CLARITYTM 결과





Brain 조직을 X-CLARITY™로 투명화 시킨 후 3D 이미지 관찰




Ordering Information

Cat no.ProductQuantity
   X-CLARITY™ ETC
C30001 X-CLARITY™ Tissue Clearing System II (Starter Kit)
   - X-CLARITY™ ETC Chamber (1 ea)
   - X-CLARITY™ ETC Control Tower (1 ea)
   - X-CLARITY™ Buffer Reservoir (1 ea)
   - X-CLARITY™ Tray (1 ea)
   - Tissue Container (Whole Mouse Brain) (5 ea)
   - Container Holder for 1 Tissue Container (1 ea)
   - Electrophoretic Tissue Clearing Solution (12 X 1 L)
1 unit
C10101 X-CLARITY™ ETC Chamber1 ea
C30002 X-CLARITY™ ETC Control Tower1 ea
C30004 X-CLARITY™ Buffer Reservoir1 ea
C32001 X-CLARITY™ Tray1 ea
C12001 Tissue Container (Whole Mouse Brain) - 20 units1 box
C12002 Container Holder for 1 Tissue Container1 ea
C12004 Mouse Brain Slice Holder (Chamber Height: 4 mm)1 ea
C12007 Whole Rat Brain Holder1 ea
C13001 Electrophoretic Tissue Clearing Solution12 X 1 L
C13100 X-CLARITY™ Mounting Solution sample5 x 1 mL
C13101 X-CLARITY™ Mounting Solution (25 mL)1 ea
C13102 X-CLARITY™ Mounting Solution (Value Pack)10 X 25 mL
C13107 X-CLARITY™ Mounting Solution Bulk Pack20 X 25 mL
C12010, C12020 Holder for 36 Mouse Brain Slices (1.5 Φ, 0.6 Φ)1 set
C12011, C12021 Holder for 6 Slices (1.5 Φ, 0.6 Φ)1 set
C12012, C12022 Holder for 1 Sample (1.5 Φ, 0.6 Φ)1 set
C12013, C12023 Holder for 6 Mouse Brains (1.5 Φ, 0.6 Φ)1 set
C12014, C12024 Holder for 48 Samples (1.5 Φ, 0.6 Φ)1 set
C12015, C12025 Holder for 192 Samples (1.5 Φ, 0.6 Φ)1 set
   X-CLARITY™ Polymerization
C20001 X-CLARITY™ Polymerization System (Starter kit)1 unit
C20002 X-CLARITY™ Heat Block for 6 x 50 mL tubes1 unit
C20003 X-CLARITY™ Heat Block for flat-bottom plates1 unit
C20004 Heat Block Lifter1 unit
C1310X X-CLARITY™ Hydrogel Solution Kit
   - X-CLARITY™ Hydrogel Solution (1 L)
   - X-CLARITY™ Polymerization Initiator (2.5 g)
1 box
C13103 X-CLARITY™ Hydrogel Solution1 L
C13104 X-CLARITY™ Polymerization Initiator2.5 g
C13108 X-CLARITY™ Hydrogel Solution Sample Kit - X-CLARITY™ Hydrogel Solution (50ml)
   - X-CLARITY™ Polymerization Initiator (125mg)
1 box


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