CLR, RLR & CDS Signaling Pathways : Invivogen 제품 소개

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PRR Ligands

Product	Specificity	Origin/Description	Endotoxin level	Working conc.	Qty	Cat no.
2’3’-cGAMP	STING Agonist	2’5’-3’5’ cyclic GMP-AMP	EndoFit™	0.1 - 100 μg/ml	500 μg 1 mg 5 mg	tlrl-nacga23 tlrl-nacga23-1 tlrl-nacga23-5
c-di-GMP	STING Agonist	3’5’ Cyclic di-GMP	EndoFit™	10 - 100 μg/ml	1 mg	tlrl-cdg
c-di-GMP VacciGrade™	STING Agonist	Sterile 3’5’ cyclic di-GMP	EndoFit™	5 - 50 μg/mouse	1 mg	vaccdg
c-di-AMP	STING Agonist	3’5’ Cyclic di-AMP	EndoFit™	1 - 100 μg/ml	1 mg	tlrl-nacda
ISD Naked	CDS Agonist	IFN stimulatory DNA	EndoFit™	100 ng - 10 μg/ml	200 μg	tlrl-isdn
3p-hpRNA	RIG-I agonist	5’ triphosphate hairpin RNA	EndoFit™	10 ng- 1 μg/ml	25 µg	tlrl-hprna
Poly(I:C) (HMW)/LyoVec	RIG-I/MDA-5 Agonists	Poly(I:C) (HMW)/LyoVec™ complexes	EndoFit™	100 ng - 1 μg/ml	100 μg	tlrl-piclv
Poly(I:C) (LMW)/LyoVec	RIG-I/MDA-5 Agonists	Poly(I:C) (LMW)/LyoVec™ complexes	EndoFit™	100 ng - 1 μg/ml	100 μg	tlrl-picwlv
TDB	Mincle Agonists	Synthetic analog of the cord factor	50 μg/ml	1 - 100 μg/ml	2 mg	tlrl-tdb
TDB vacciGrade™	Mincle Agonists	Preclinical grade TDB	50 μg/ml	50 μg/mouse	2 mg	vac-tdb
Beta-Glucan Peptide	Dectin-1 Agonists	Beta-glucan from Trametes versicolor	EndoFit™	10 - 100 μg/ml	50 mg	tlrl-bgp
Furfurman	Dectin-2 Agonists	Malassezia furfur cell wall preparation	EndoFit™	100 ng - 10 μg/ml	10 mg	tlrl-ffm

Relate product_Reporter Cell Line

Cell line	Product	Description	Reporter	Cat no.
CLR REPORTER CELLS
HEK293	HEK-Blue™ hDectin-1a	Human Dectin-1a / NF-κB-reporter cells	SEAP	hkb-hdect1a
HEK293	HEK-Blue™ hDectin-1b	Human Dectin-1b / NF-κB-reporter cells	SEAP	hkb-hdect1b
NOD REPORTER CELLS
HEK293	HEK-Blue™ hNOD1	Human NOD1 / NF-κB-reporter cells	SEAP	hkb-hnod1
	HEK-Blue™ hNOD2	Human NOD2 / NF-κB-reporter cells	SEAP	hkb-hnod2
	HEK-Blue™ mNOD1	Mouse NOD1 / NF-κB-reporter cells	SEAP	hkb-mnod1
	HEK-Blue™ mNOD2	Mouse NOD2 / NF-κB-reporter cells	SEAP	hkb-mnod2
RLR REPORTER CELLS
HEK293	HEK-Lucia™ RIG-I	Mouse RIG-I / IRF-reporter cells	Lucia	hkl-hrigi
TLR REPORTER CELLS
HEK293	HEK-Blue™ hTLR2	Human TLR2 / NF-κB-reporter cells	SEAP	hkb-htlr2
	HEK-Blue™ hTLR3	Human TLR3 / NF-κB-reporter cells	SEAP	hkb-htlr3
	HEK-Blue™ hTLR4	Human TLR4-MD2-CD14 / NF-κB-reporter cells	SEAP	hkb-htlr4
	HEK-Blue™ hTLR5	Human TLR5 / NF-κB-reporter cells	SEAP	hkb-htlr5
	HEK-Blue™ hTLR7	Human TLR7 / NF-κB-reporter cells	SEAP	hkb-htlr7
	HEK-Blue™ hTLR8	Human TLR8 / NF-κB-reporter cells	SEAP	hkb-htlr8
	HEK-Blue™ hTLR9	Human TLR9 / NF-κB-reporter cells	SEAP	hkb-htlr9
	HEK-Dual™ hTLR2	Double readout (NF-κB / IL8) TLR2 human reporter cells, Lucia knocked in IL8	SEAP / Lucia	hkd-htlr2ni
	HEK-Dual™ hTLR3	Double readout (NF-κB / IL8) TLR3 human reporter cells, Lucia knocked in IL8	SEAP / Lucia	hkd-htlr3ni
	HEK-Dual™ hTLR5	Double readout (NF-κB / IL8) TLR5 human reporter cells, Lucia knocked in IL8	SEAP / Lucia	hkd-htlr5ni
	HEK-Dual™ hTLR9	Double readout (NF-κB / IL8) TLR9 human reporter cells, Lucia knocked in IL8	SEAP / Lucia	hkd-htlr9ni
STING VARIANT REPORTER CELLS
HEK293	293T-Dual™ hSTING-A162	Double readout (ISRE / IFN-β) human reporter cells, Lucia knocked in IFN-β, S162A human STING transfected	SEAP / Lucia	293d-a162
THP-1	THP1-Dual™ KI-hSTING-A162	NF-κB and IRF human reporter cells, S162A human STING knocked in; DMXAA sensitive isoform	SEAP / Lucia	thpd-a162

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다양한 Inhibitors TLR & NLR Signaling Pathways

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