| PRODUCT | DESCRIPTION | QTY | CAT. CODE |
| Cytokines |
Anti-mIL-1α-mIgG1
| Recombinant mouse mAb against mIL-1α (clone 6H7). For in vitro use.
| 200 µg
| mil1a-mab9-02
|
| Anti-mIL-1α-mIgG1 InvivoFit™ | Recombinant mouse mAb against mIL-1α (clone 6H7). For in vivo use.
| 1mg | mil1a-mab9-1
|
Anti-mIL-1β-mIgG1
| Recombinant mouse mAb against mIL-1β (clone 7E3). For in vitro use.
| 200 µg
| mil1b-mab9-02
|
Anti-mIL-1β-mIgG1 InvivoFit™
| Recombinant mouse mAb against mIL-1β (clone 7E3). For in vivo use.
| 1mg / 10 mg | mil1b-mab9-1/-10 |
Anti-mIL-6-mIgG1e3
| Recombinant mouse mAb against mIL-6 (clone 10F9). For in vitro use.
| 200 µg
| mil6-mab15-02
|
Anti-mIL-6-mIgG1e3 InvivoFit™
| Recombinant mouse mAb against mIL-6 (clone 10F9). For in vivo use.
| 1mg / 10 mg
| mil6-mab15-1/mil6-mab15-10 |
Anti-mIL-13-mIgG1
| Recombinant mouse mAb against mIL-13 (clone 8H8). For in vitro use.
| 200 µg
| mil13-mab9-02
|
Anti-mIL-13-mIgG1 InvivoFit™
| Recombinant mouse mAb against mIL-13 (clone 8H8). For in vivo use.
| 1 mg
| mil13-mab9-1
|
Anti-mIL-28b-mIgG1
| Recombinant mouse mAb against mIL-28B (clone 3C11). For in vitro use.
| 200 µg
| mil28b-mab9-02
|
Anti-mIL-28b-mIgG1 InvivoFit™
| Recombinant mouse mAb against mIL-28B (clone 3C11). For in vivo use.
| 1 mg
| mil28b-mab9-1
|
| In vivo Lymphocyte markers mAbs |
| Anti-mCD3-mIgG2a InvivoFit™ | 145-2C11-derived mouse mAb against murine CD3 | 1mg / 10 mg | mcd3-mab10-1/-10 |
| Anti-mCD4-mIgG2a InvivoFit™ | GK1.5-derived mouse mAb against murine CD4 | 1mg / 10 mg | mcd4-mab10-1/-10 |
| Anti-mCD8-mIgG2a InvivoFit™ | YTS169.4-derived mouse mAb against murine CD8 | 1mg / 10 mg | mcd8-mab10-1/-10 |
| Anti-mCD20-mIgG2a InvivoFit™ | 18B12-derived mouse monoclonal antibody against murine CD20 | 1mg / 10 mg | mcd20-mab10-1/-10 |
| Anti-mCD25-PC-mIgG2a InvivoFit™ | PC-61.5.3-derived monoclonal antibody against murine CD25 (blocking) | 1mg / 10 mg | mcd25c1-mab10-1/-10 |
| Anti-mCD25-7D4-mIgG2a InvivoFit™ | 7D4-derived monoclonal antibody against murine CD25 (non-blocking) | 1mg / 10 mg | mcd25c2-mab10-1/-10 |
| In vivo immune checkpoint blocking mAbs |
| Anti-mCTLA4-mIgG2a InvivoFit™ | 9D9-derived mouse mAb against murine CTLA-4 | 1mg / 10 mg | mctla4-mab10-1/-10 |
| Anti-mPD-1-mIgG1e3 InvivoFit™ | RMP1-14-derived mouse mAb against murine PD-1 | 1mg / 10 mg | mpd1-mab15-1/-10 |
| Anti-PD-L1-mIgG1e3 InvivoFit™ | Murinized atezolizumab mouse mAb against PD-L1 | 1mg / 10 mg | pdl1-mab15-1/-10 |
| Anti-mTIGIT-mIgG2a InvivoFit™ | 10A7-derived monoclonal antibody against murine TIGIT | 1mg / 10 mg | mtigit-mab10-1/-10 |
| In vivo tumor-associated antigen mAbs |
| Anti-mgp75-mIgG2a InvivoFit™ | TA99-derived mouse mAb against murine gp75 | 1mg / 10 mg | mgp75-mab10-1/-10 |
| In vivo isotype controls |
| Anti-β-Gal-mIgG1e3 InvivoFit™ | Mouse IgG1e3 isotype control | 1mg / 10 mg | bgal-mab15-1/-10 |
| Anti-β-Gal-mIgG2a InvivoFit™ | Mouse IgG2a isotype control | 1mg / 10 mg | bgal-mab10-1/-10 |
Mouse Anti-Mouse mAbs
In vivo 마우스 실험을 위한 Recombinant monoclonal antibody
InvivoGen은 mouse에 반복적인 injection 시 immunogenicity (면역원성)을 제한하도록 설계된 InvivoFit™ recombinant mouse 혹은 Murinized anti-mouse monoclonal antibody (mAb)를 제공합니다.
InvivoGen의 mAb는 Chinese hamster ovary (CHO) cell에서 생산됩니다. In vivo 마우스 실험에 사용 가능한 high-quality의 InvivoFit™ 등급의 아래와 같은 단백질을 타겟하는 mAb를 제공합니다.
* Key Features
Xenogeneic sequence (이종 서열)의 최소 사용은 mAb의 immunogenicity를 제한합니다. mAb 활성을 평가하기 위한 murine in vivo 마우스 실험에서 반복적인 injection 시 직면하는 주요 문제는 mouse origin의 sequence가 아닌 경우 발생하는 항체 성능의 감소 및 손실입니다.
Mouse에 반복적인 injection은 host에 의한 anti-species antibody 생성을 유도합니다 (예 : mAb가 rat에서 생성된 경우 anti-rat antibody). 이러한 현상은 mouse가 아닌 다른 종 (host)의 sequence 비율이 높을수록 증가합니다.
Xenogeneic sequence를 mouse sequence로 대체할 경우 항체 immunogenicity가 감소하며, in vivo 환경에서 활성을 유지할 수 있습니다.
* Ordering information
mil6-mab15-1/mil6-mab15-10
[학술문의] T. 031-728-3236 E. technical@dawinbio.com