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기 타[Bio X Cell] PD-1 / PD-L1 연구 목적에 적합한 항체를 찾고 계신가요?

Bio X Cell
조회수 333

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PD-1 / PD-L1 연구를 위한 다양한 항체를 한눈에


PD-1과 PD-L1은 T cell 면역반응을 조절하는 대표적인 immune checkpoint protein으로, 두 단백질 간 결합은 T cell activation을 억제하고 tumor immune evasion에 중요한 역할을 합니다.


Bio X Cell은 다양한 실험 모델과 연구 목적에 맞게 anti-mouse 및 anti-human PD-1 / PD-L1 antibodies를 제공하고 있습니다.


연구 대상 species, clone, antibody format 및 application에 따라 적합한 monoclonal (InVivoMAb™ & InVivoPlus™) 및 recombinant (RecombiMAb™) 항체를 선택할 수 있습니다.

PD-1 (CD279)

0f5bd5a3be340.png  Anti-Mouse

CloneFormatCat. NoIsotypeApplication
RPM1-14















Monoclonal

BE0146Rat IgG2a, κ

in vivo Blocking of PD-1/PD-L Signaling

in vitro Organoids/Organ-on-Chip

Monoclonal 
(Ultra-Pure)		BP0146
Rat IgG2a, κ

in vivo Blocking of PD-1/PD-L Signaling

in vitro Organoids/Organ-on-Chip

Recombinant 
(Ultra-Pure)		CP094Mouse IgG2c, κ
in vivo Blocking of PD-1/PD-L Signaling
Recombinant 
(Ultra-Pure)
CP157Mouse IgG2a
in vivo Blocking of PD-1/PD-L Signaling
Recombinant 
(Ultra-Pure)
CP162Mouse IgG1
in vivo Blocking of PD-1/PD-L Signaling
Recombinant 
(Ultra-Pure)
CP182Rat IgG2a, κ
in vivo Blocking of PD-1/PD-L Signaling
Recombinant 
(Ultra-Pure)
CP002Mouse IgG1
(D265A) *Fc-silenced 		in vivo Blocking of PD-1/PD-L Signaling
Recombinant 
(Ultra-Pure)
CP151Mouse IgG2a (D265A) *Fc-silenced
in vivo Blocking of PD-1/PD-L Signaling
Recombinant 
(Ultra-Pure)
CP153
Mouse IgG2a 
(LALA-PG) *Fc-silenced
in vivo Blocking of PD-1/PD-L Signaling
29F.1A12











Monoclonal
BE0273Rat IgG2a
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization,
in vitro Organoids/Organ-on-Chip,
Flow cytometry, IHC (frozen), IF, WB 
Monoclonal 
(Ultra-Pure)
BP0273Rat IgG2a
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization,
in vitro Organoids/Organ-on-Chip,
Flow cytometry, IHC (frozen), IF, WB
Recombinant 
(Ultra-Pure)
CP159Mouse IgG2a
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization,
Flow cytometry, IHC (frozen), IF, WB
Recombinant 
(Ultra-Pure)
CP178Mouse IgG1
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization,
Flow cytometry, IHC (frozen), IF, WB
Recombinant 
(Ultra-Pure)
CP185Rat IgG2a, κ
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization,
Flow cytometry, IHC (frozen), IF, WB
Recombinant 
(Ultra-Pure)
CP005Mouse IgG1 (D265A), κ
 *Fc-silenced
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization,
Flow cytometry, IHC (frozen), IF, WB
Recombinant 
(Ultra-Pure)
CP155Mouse IgG2a (LALA-PG) *Fc-silenced
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization,
Flow cytometry, IHC (frozen), IF, WB
J43

Monoclonal
BE0033-2Armenian hamster IgG
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization, WB
Monoclonal 
(Ultra-Pure)
BP0033-2Armenian hamster IgG
in vivo blocking of PD-1/PD-L signaling,
in vitro PD-1 neutralization, WB
J116Monoclonal
BE0188Mouse IgG1, κ
in vitro PD-1 neutralization,

in vivo PD-1 blockade in humanized mice

in vitro Organoids/Organ-on-Chip

J110Monoclonal
BE0193Mouse IgG1, κ
in vivo PD-1 blockade in humanized mice, Flow cytometry

      * Ultra-Pure: 항체–항원 결합 검증, 항체 응집 검증, 동물성 병원체 real-time PCR screening, 낮은 Endotoxin (≤0.5 EU/mg) 

3aa332867f5c0.png   Anti-Human

Reference DrugFormatCat. NoIsotypeApplication

Pembrolizumab


BiosimilarSIM0010Human IgG4
in vivo Blocking of PD-1/PD-L Signaling,
in vitro Blocking of PD-1/PD-L Signaling,
in vitro functional assay

Nivolumab


Biosimilar
SIM0003Human IgG4
in vitro PD-1 neutralization,
in vivo blocking of PD-1/PD-L signaling,
in vitro functional assay,
in vivo functional assay,
Flow Cytometry, IHC, WB

Cemiplimab 

Biosimilar
SIM0037Human IgG4, κ
Blocking of PD-1/PD-L signaling,
Functional assays, ELISA

Tislelizumab

Biosimilar
SIM0038Human IgG4, κ
Blocking of PD-1/PD-L signaling,
Functional assays, ELISA



dcc20d7f8fb9e.png& 45291312ee4ae.png  Anti-Mouse/Human Phosphorylated PD-1 (CD279)


CloneFormatCat. NoIsotypeApplicaton
407.6G12
Monoclonal
BE0387
Mouse IgG2a, κ
Flow Cytometry, WB

PD-L1 (B7-H1)

0f5bd5a3be340.png  Anti-Mouse

CloneFormatCat. NoIsotypeApplication
10F.9G2

Monoclonal

BE0101
Rat IgG2b, κ

in vivo PD-L1 blockade,
in vitro PD-L1 blockade,
IF, IHC (frozen), Flow cytometry, WB,
in vitro Organoids/Organ-on-Chip 














Monoclonal
(Ultra-Pure)		BP0101Rat IgG2b, κ  

in vivo PD-L1 blockade,
in vitro PD-L1 blockade,
IF, IHC (frozen), Flow cytometry, WB,
in vitro Organoids/Organ-on-Chip

Recombinant 
(Ultra-Pure)
CP158Mouse IgG2a, κ
in vivo PD-L1 blockade,
IF, IHC (frozen), Flow cytometry, WB
Recombinant 
(Ultra-Pure)
CP168Mouse IgG1
in vivo PD-L1 blockade,
IF, IHC (frozen), Flow cytometry, WB
Recombinant
(Ultra-Pure)
CP184Rat IgG2b, κ
in vivo PD-L1 blockade,
IF, IHC (frozen), Flow cytometry, WB
Recombinant
(Ultra-Pure)
CP001Mouse IgG1 (D265A), κ
 *Fc-silenced
in vivo PD-L1 blockade,
IF, IHC (frozen), Flow cytometry, WB
Recombinant
(Ultra-Pure)
CP154Mouse IgG2a
in vivo PD-L1 blockade,
IF, IHC (frozen), Flow cytometry, WB
10F.2H11
Monoclonal
BE0361Rat IgG2b, κ
in vivo PD-L1 blockade,
in vitro PD-L1 blockade,
ELISA, Flow cytometry 
368A.4H1
Monoclonal
BE0383Mouse IgG1, κ
in vivo PD-L1 blockade,
in vitro PD-L1 blockade,
Flow cytometry

      * Ultra-Pure: 항체–항원 결합 검증, 항체 응집 검증, 동물성 병원체 real-time PCR screening, 낮은 Endotoxin (≤0.5 EU/mg) 

3aa332867f5c0.png  Anti-Human

Clone /
Reference Drug		FormatCat. NoIsotypeApplication
29E.2A3 
Monoclonal
BE0285Mouse IgG2b, κ
in vitro PD-L1 blockade,
in vitro Organoids/Organ-on-Chip
Functional assays, Flow Cytometry, 
IHC (frozen)
368A.4H1 
Monoclonal
BE0383Mouse IgG1, κ
in vivo PD-L1 blockade,
in vitro PD-L1 blockade,
Flow Cytometry
Atezolizumab 
BiosimilarSIM0009Human IgG1
in vivo PD-L1 blockade,
Flow Cytometry, WB
Avelumab
Biosimilar
SIM0021Human IgG1, λ
in vitro PD-L1 blockade,
in vtro functional assay, ELISA
Durvalumab
Biosimilar
SIM0027Human IgG1, κ
Functional Assay, Flow Cytometry, 
WB, ELISA, 



* 학술 문의: (주)다윈바이오

  Tel. 031-728-3231 / E-mail. dawinbio@dawinbio.com

#BioXCell  #InVivo #항체 #고순도 #Endotoxin #PD-1 #PD-1L1 #Checkpoint#Inhinbitor
#Biosimilar #InVivoSIM #InVivoMAb #Monoclona #InvVivoPlus #Reombinant #RecombiMAb
#Murine #Antibody #다윈바이오 #DAWINBIO


[Bio X Cell] Fab / F(ab′)₂ Antibody Fragments [Bio X Cell] Recombinant Proteins - 세포 활성화부터 분화까지 기능 연구를 위한 단백질
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